Myelin oligodendrocyte glycoprotein antibodies associated disease: how important are B cells?
نویسندگان
چکیده
منابع مشابه
Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders
Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disor...
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OBJECTIVE To determine whether myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) were predictive of a demyelination phenotype in children presenting with acquired demyelinating syndrome (ADS). METHOD Sixty-five children with a first episode of ADS (12 acute disseminated encephalomyelitis, 24 optic neuritis, 18 transverse myelitis, 11 other clinically isolated syndrome) were identified ...
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OBJECTIVE To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and control individuals. DESIGN Prospective case-control series. SETTING Academic referral center. PATIENTS Twenty-six controls with noninflammatory neurologic disease and 35 patients with MS donated serum and CSF for recombinant...
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OBJECTIVES To investigate the differences of clinical features, cerebrospinal fluid (CSF), MRI findings and response to steroid therapies between patients with optic neuritis (ON) who have myelin oligodendrocyte glycoprotein (MOG) antibodies and those who have seronegative ON. SETTING We recruited participants in the department of neurology and ophthalmology in our hospital in Japan. METHOD...
متن کاملAnti-myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.
Can serum antibodies to myelin oligodendrocyte glycoprotein (MOG) be used as a marker of multiple sclerosis (MS) or to predict the course of MS? Recent articles present conflicting data in response to these questions. Berger et al.1 tested for presence of serum antibodies to MOG in patients experiencing a first clinically isolated syndrome suggestive of MS. Those who progressed almost invariabl...
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ژورنال
عنوان ژورنال: Developmental Medicine & Child Neurology
سال: 2019
ISSN: 0012-1622,1469-8749
DOI: 10.1111/dmcn.14370